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The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities.
Bapiro, Tashinga E; Martin, Scott; Wilkinson, Stephen D; Orton, Alexandra L; Hariparsad, Niresh; Harlfinger, Stephanie; McGinnity, Dermot F.
Afiliação
  • Bapiro TE; Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Cambridge, United Kingdom (T.E.B., S.M., S.D.W., A.L.O., S.H., D.F.M.) and Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Boston, Massachusetts (N.H.) tashinga.bapiro1@astraze
  • Martin S; Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Cambridge, United Kingdom (T.E.B., S.M., S.D.W., A.L.O., S.H., D.F.M.) and Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Boston, Massachusetts (N.H.).
  • Wilkinson SD; Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Cambridge, United Kingdom (T.E.B., S.M., S.D.W., A.L.O., S.H., D.F.M.) and Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Boston, Massachusetts (N.H.).
  • Orton AL; Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Cambridge, United Kingdom (T.E.B., S.M., S.D.W., A.L.O., S.H., D.F.M.) and Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Boston, Massachusetts (N.H.).
  • Hariparsad N; Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Cambridge, United Kingdom (T.E.B., S.M., S.D.W., A.L.O., S.H., D.F.M.) and Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Boston, Massachusetts (N.H.).
  • Harlfinger S; Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Cambridge, United Kingdom (T.E.B., S.M., S.D.W., A.L.O., S.H., D.F.M.) and Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Boston, Massachusetts (N.H.).
  • McGinnity DF; Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Cambridge, United Kingdom (T.E.B., S.M., S.D.W., A.L.O., S.H., D.F.M.) and Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Boston, Massachusetts (N.H.).
Drug Metab Dispos ; 51(7): 892-901, 2023 Jul.
Article em En | MEDLINE | ID: mdl-37041083
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Hidrocarboneto de Aril Hidroxilases Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Hidrocarboneto de Aril Hidroxilases Idioma: En Ano de publicação: 2023 Tipo de documento: Article