Subgingival microbial diversity and respiratory decline: A cross-sectional study.
J Clin Periodontol
; 50(7): 921-931, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-37051866
ABSTRACT
AIM:
To investigate whether there is an association between subgingival microbial diversity and reduced respiratory function. MATERIALS ANDMETHODS:
A group of dentate 58-72-year-old men in Northern Ireland had a comprehensive periodontal examination including subgingival plaque sampling. DNA was extracted from plaque samples and the V1-V3 regions of the 16S rRNA gene were analysed by high-throughput sequencing and a microbial diversity index (MDI) was derived. Spirometry measurements were made using a wedge bellows spirometer. The primary outcome variable of interest was the percentage of predicted forced expiratory volume in 1 s (% predicted FEV1 ). Analysis included multiple linear regression with adjustment for various confounders.RESULTS:
Five-hundred and seven men were included in the analysis. The mean age was 63.6 years (SD = 3.1). Of these, 304 (60.0%) men had no or mild periodontitis, 105 (20.7%) had moderate periodontitis and 98 (19.3%) had severe periodontitis. Multiple linear regression analysis showed that a one unit increase in MDI was associated with a 0.71% loss (95% confidence interval 0.06%-1.35%; p = .03) in % predicted FEV1 after adjustment for all confounders.CONCLUSIONS:
In this group of dentate men from Northern Ireland, subgingival microbial diversity was associated with reduced respiratory function.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Periodontite
/
Placa Dentária
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article