Engineered skin bacteria induce antitumor T cell responses against melanoma.
Science
; 380(6641): 203-210, 2023 04 14.
Article
em En
| MEDLINE
| ID: mdl-37053311
ABSTRACT
Certain bacterial colonists induce a highly specific T cell response. A hallmark of this encounter is that adaptive immunity develops preemptively, in the absence of an infection. However, the functional properties of colonist-induced T cells are not well defined, limiting our ability to understand anticommensal immunity and harness it therapeutically. We addressed both challenges by engineering the skin bacterium Staphylococcus epidermidis to express tumor antigens anchored to secreted or cell-surface proteins. Upon colonization, engineered S. epidermidis elicits tumor-specific T cells that circulate, infiltrate local and metastatic lesions, and exert cytotoxic activity. Thus, the immune response to a skin colonist can promote cellular immunity at a distal site and can be redirected against a target of therapeutic interest by expressing a target-derived antigen in a commensal.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Neoplasias Cutâneas
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Staphylococcus epidermidis
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Melanoma
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Antígenos de Neoplasias
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article