AKT activity orchestrates marginal zone B cell development in mice and humans.
Cell Rep
; 42(4): 112378, 2023 04 25.
Article
em En
| MEDLINE
| ID: mdl-37060566
ABSTRACT
The signals controlling marginal zone (MZ) and follicular (FO) B cell development remain incompletely understood. Here, we show that AKT orchestrates MZ B cell formation in mice and humans. Genetic models that increase AKT signaling in B cells or abolish its impact on FoxO transcription factors highlight the AKT-FoxO axis as an on-off switch for MZ B cell formation in mice. In humans, splenic immunoglobulin (Ig) D+CD27+ B cells, proposed as an MZ B cell equivalent, display higher AKT signaling than naive IgD+CD27- and memory IgD-CD27+ B cells and develop in an AKT-dependent manner from their precursors in vitro, underlining the conservation of this developmental pathway. Consistently, CD148 is identified as a receptor indicative of the level of AKT signaling in B cells, expressed at a higher level in MZ B cells than FO B cells in mice as well as humans.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Proteínas Proto-Oncogênicas c-akt
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article