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AKT activity orchestrates marginal zone B cell development in mice and humans.
Cox, Eva-Maria; El-Behi, Mohamed; Ries, Stefanie; Vogt, Johannes F; Kohlhaas, Vivien; Michna, Thomas; Manfroi, Benoît; Al-Maarri, Mona; Wanke, Florian; Tirosh, Boaz; Pondarre, Corinne; Lezeau, Harry; Yogev, Nir; Mittenzwei, Romy; Descatoire, Marc; Weller, Sandra; Weill, Jean-Claude; Reynaud, Claude-Agnès; Boudinot, Pierre; Jouneau, Luc; Tenzer, Stefan; Distler, Ute; Rensing-Ehl, Anne; König, Christoph; Staniek, Julian; Rizzi, Marta; Magérus, Aude; Rieux-Laucat, Frederic; Wunderlich, F Thomas; Hövelmeyer, Nadine; Fillatreau, Simon.
Afiliação
  • Cox EM; Institute for Molecular Medicine Mainz, University Hospital of Mainz, 55131 Mainz, Germany.
  • El-Behi M; Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, 156-160, rue de Vaugirard, 75015 Paris, France.
  • Ries S; Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, 10117 Berlin, Germany.
  • Vogt JF; Institute for Molecular Medicine Mainz, University Hospital of Mainz, 55131 Mainz, Germany.
  • Kohlhaas V; Max Planck Institute for Metabolism Research Cologne, 50931 Cologne, Germany; Institute for Genetics, University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), 50931 Cologne, Germany; Center for Molecular Medicine Col
  • Michna T; Institute for Immunology, University Medical Centre of the Johannes-Gutenberg University Mainz, Mainz, Germany.
  • Manfroi B; Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, 156-160, rue de Vaugirard, 75015 Paris, France.
  • Al-Maarri M; Max Planck Institute for Metabolism Research Cologne, 50931 Cologne, Germany; Institute for Genetics, University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), 50931 Cologne, Germany; Center for Molecular Medicine Col
  • Wanke F; Institute for Molecular Medicine Mainz, University Hospital of Mainz, 55131 Mainz, Germany.
  • Tirosh B; The Hebrew University of Jerusalem, Institute for Drug Research, Jerusalem, Israel.
  • Pondarre C; Service de Pédiatrie Générale, Centre de Référence de la Drépanocytose, Centre Intercommunal de Créteil, Créteil, France; Inserm U955, Université Paris XII, Créteil, France.
  • Lezeau H; Service de Pédiatrie Générale, Centre de Référence de la Drépanocytose, Centre Intercommunal de Créteil, Créteil, France; Inserm U955, Université Paris XII, Créteil, France.
  • Yogev N; Faculty of Medicine, Department of Dermatology, University of Cologne, 50931 Cologne, Germany.
  • Mittenzwei R; Institute for Molecular Medicine Mainz, University Hospital of Mainz, 55131 Mainz, Germany.
  • Descatoire M; Laboratory of Immune Inherited Disorders, Department of Immunology and Allergology Lausanne Hospital CHUV, Lausanne, Switzerland.
  • Weller S; Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, 156-160, rue de Vaugirard, 75015 Paris, France.
  • Weill JC; Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, 156-160, rue de Vaugirard, 75015 Paris, France.
  • Reynaud CA; Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, 156-160, rue de Vaugirard, 75015 Paris, France.
  • Boudinot P; Université Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.
  • Jouneau L; Université Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.
  • Tenzer S; Institute for Immunology, University Medical Centre of the Johannes-Gutenberg University Mainz, Mainz, Germany; Research Centre for Immunotherapy (FZI), University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany; Helmholtz Institute for Translational Oncology Mainz (HI-TRON
  • Distler U; Institute for Immunology, University Medical Centre of the Johannes-Gutenberg University Mainz, Mainz, Germany.
  • Rensing-Ehl A; Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • König C; Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; University of Freiburg, Faculty of Biology, Schaenzlestrasse 1, 79104 Freiburg, Germany.
  • Staniek J; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Rizzi M; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Division
  • Magérus A; Université Paris Cité, Institut Imagine, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, 75015 Paris, France.
  • Rieux-Laucat F; Université Paris Cité, Institut Imagine, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, 75015 Paris, France.
  • Wunderlich FT; Max Planck Institute for Metabolism Research Cologne, 50931 Cologne, Germany; Institute for Genetics, University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), 50931 Cologne, Germany; Center for Molecular Medicine Col
  • Hövelmeyer N; Institute for Molecular Medicine Mainz, University Hospital of Mainz, 55131 Mainz, Germany; Research Centre for Immunotherapy (FZI), University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany. Electronic address: hoevelme@uni-mainz.de.
  • Fillatreau S; Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, 156-160, rue de Vaugirard, 75015 Paris, France; Université de Paris Cité, Paris Descartes, Faculté de Médecine, Paris, France; AP-HP, Hôpital Necker Enfants Malades, Paris, France. Electronic address: simonfillatreau@googlemail.com.
Cell Rep ; 42(4): 112378, 2023 04 25.
Article em En | MEDLINE | ID: mdl-37060566
ABSTRACT
The signals controlling marginal zone (MZ) and follicular (FO) B cell development remain incompletely understood. Here, we show that AKT orchestrates MZ B cell formation in mice and humans. Genetic models that increase AKT signaling in B cells or abolish its impact on FoxO transcription factors highlight the AKT-FoxO axis as an on-off switch for MZ B cell formation in mice. In humans, splenic immunoglobulin (Ig) D+CD27+ B cells, proposed as an MZ B cell equivalent, display higher AKT signaling than naive IgD+CD27- and memory IgD-CD27+ B cells and develop in an AKT-dependent manner from their precursors in vitro, underlining the conservation of this developmental pathway. Consistently, CD148 is identified as a receptor indicative of the level of AKT signaling in B cells, expressed at a higher level in MZ B cells than FO B cells in mice as well as humans.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Proteínas Proto-Oncogênicas c-akt Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Proteínas Proto-Oncogênicas c-akt Idioma: En Ano de publicação: 2023 Tipo de documento: Article