Radiotheranostics in advanced prostate cancer: Current and future directions.
Prostate Cancer Prostatic Dis
; 27(1): 11-21, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-37069330
ABSTRACT
The discovery of small molecules that target the extracellular domain of prostate-specific membrane antigen (PSMA) has led to advancements in diagnostic imaging and the development of precision radiopharmaceutical therapies. In this review, we present the available existing data and highlight the key ongoing clinical evaluations of PSMA-based imaging in the management of primary, biochemically recurrent, and metastatic prostate cancer. We also discuss clinical studies that explore the use of PSMA-based radiopharmaceutical therapy (RPT) in metastatic prostate cancer and forthcoming trials that investigate PSMA RPT in earlier disease states. Multidisciplinary collaboration in clinical trial design and therapeutic administration is critical to the continued progress of this evolving radiotheranostics field.
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1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article