Pathogens identified in the internal tissues and placentas of stillbirths: results from the prospective, observational PURPOSe study.
BJOG
; 130(10): 1238-1246, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37069731
ABSTRACT
OBJECTIVE:
To examine internal organ tissues and placentas of stillbirths for various pathogens.DESIGN:
Prospective, observational study. SETTINGS Three study hospitals in India and a large maternity hospital in Pakistan. POPULATION Stillborn infants delivered in a study hospital.METHODS:
A prospective observational study. MAIN OUTCOMEMEASURES:
Organisms identified by pathogen polymerase chain reaction (PCR) in internal organs and placental tissues of stillbirths.RESULTS:
Of 2437 stillbirth internal tissues, 8.3% (95% CI 7.2-9.4) were positive. Organisms were most commonly detected in brain (12.3%), cerebrospinal fluid (CSF) (9.5%) and whole blood (8.4%). Ureaplasma urealyticum/parvum was the organism most frequently detected in at least one internal organ (6.4% of stillbirths and 2% of all tissues). Escherichia coli/Shigella was the next most common (4.1% one or more internal organ tissue sample and 1.3% of tissue samples), followed by Staphylococcus aureus in at least one internal organ tissue (1.9% and 0.9% of all tissues). None of the other organisms was found in more than 1.4% of the tissue samples in stillbirths or more than 0.6% of the internal tissues examined. In the placenta tissue, membrane or cord blood combined, 42.8% (95% CI 40.2-45.3) had at least one organism identified, with U. urealyticum/parvum representing the most commonly identified (27.8%).CONCLUSIONS:
In about 8% of stillbirths, there was evidence of a pathogen in an internal organ. Ureaplasma urealyticum/parvum was the most common organism found in the placenta and in the internal tissues, especially in the fetal brain.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Natimorto
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article