Combining local conformational preferences and solvophobic effects in helical aromatic oligoamide foldamers.
Org Biomol Chem
; 21(17): 3525-3530, 2023 May 03.
Article
em En
| MEDLINE
| ID: mdl-37070553
ABSTRACT
Aromatic oligoamide foldamers were designed using a newly-developed monomer so that helical folding was promoted by both local conformation preferences and solvophobic effects. Solid phase synthesis provided quick access to the desired sequences. Sharp solvent-driven conformational transitions that depended on sequence length were evidenced by both NMR and UV absorption spectroscopies.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
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Article