Mechanistic Middle-Out Physiologically Based Toxicokinetic Modeling of Transporter-Dependent Disposition of Perfluorooctanoic Acid in Humans.

Lin, Jieying; Chin, Sheng Yuan; Tan, Shawn Pei Feng; Koh, Hor Cheng; Cheong, Eleanor Jing Yi; Chan, Eric Chun Yong; Chan, James Chun Yip

Lin, Jieying; Chin, Sheng Yuan; Tan, Shawn Pei Feng; Koh, Hor Cheng; Cheong, Eleanor Jing Yi; Chan, Eric Chun Yong; Chan, James Chun Yip.

Afiliação

Lin J; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore.
Chin SY; A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #06-06, Singapore 138648 , Republic of Singapore.
Tan SPF; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore.
Koh HC; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #01-02, Singapore 138669, Republic of Singapore.
Cheong EJY; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore.
Chan ECY; A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #06-06, Singapore 138648 , Republic of Singapore.
Chan JCY; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore.

Environ Sci Technol ; 57(17): 6825-6834, 2023 05 02.

Article em En | MEDLINE | ID: mdl-37072124

Assuntos

Caprilatos; Fluorocarbonos; Humanos; Toxicocinética; Fluorocarbonos/farmacocinética; Medição de Risco; Proteínas de Membrana Transportadoras; Modelos Biológicos

Palavras-chave

PBTK model; PFOA; half-life (t1/2); in vitro-to-in vivo extrapolation; quantitative proteomics; renal transporters

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caprilatos / Fluorocarbonos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caprilatos / Fluorocarbonos Idioma: En Ano de publicação: 2023 Tipo de documento: Article