Immunoinformatics and Reverse Vaccinology Driven Predication of a Multi-epitope Vaccine against <i>Borrelia burgdorferi</i> and Validation through <i>in silico</i> Cloning and Immune Simulation.

Hussain, Zulfiqar; Hayat, Chandni; Shahab, Muhammad; Sikandar, Ramin; Bibi, Haleema; Kamil, Atif; Zheng, Guojun; Liang, Chaoqun

Immunoinformatics and Reverse Vaccinology Driven Predication of a Multi-epitope Vaccine against Borrelia burgdorferi and Validation through in silico Cloning and Immune Simulation.

Hussain, Zulfiqar; Hayat, Chandni; Shahab, Muhammad; Sikandar, Ramin; Bibi, Haleema; Kamil, Atif; Zheng, Guojun; Liang, Chaoqun.

Afiliação

Hussain Z; Computational Medicinal Chemistry Laboratory, Department of Chemistry, UCSS, Abdul Wali Khan University, Mardan, Pakistan.
Hayat C; Computational Medicinal Chemistry Laboratory, Department of Chemistry, UCSS, Abdul Wali Khan University, Mardan, Pakistan.
Shahab M; State Key Laboratories of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Sikandar R; Computational Medicinal Chemistry Laboratory, Department of Chemistry, UCSS, Abdul Wali Khan University, Mardan, Pakistan.
Bibi H; Computational Medicinal Chemistry Laboratory, Department of Chemistry, UCSS, Abdul Wali Khan University, Mardan, Pakistan.
Kamil A; Computational Medicinal Chemistry Laboratory, Department of Chemistry, UCSS, Abdul Wali Khan University, Mardan, Pakistan.
Zheng G; State Key Laboratories of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Liang C; State Key Laboratories of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

Curr Pharm Des ; 29(19): 1504-1515, 2023.

Article em En | MEDLINE | ID: mdl-37073655

Assuntos

Borrelia burgdorferi; Vacinas; Humanos; Epitopos de Linfócito T/química; Simulação de Acoplamento Molecular; Vacinologia/métodos; Escherichia coli; Epitopos de Linfócito B/química; Clonagem Molecular; Biologia Computacional; Vacinas de Subunidades Antigênicas/química

Palavras-chave

B cell; Borrelia burgdorferi; Epitope; Immunoinformatics; T cell; Vaccine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas / Borrelia burgdorferi Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas / Borrelia burgdorferi Idioma: En Ano de publicação: 2023 Tipo de documento: Article