Overexpression of miRNA 26a and 26b with MMP-9 are valuable diagnostic biomarkers for colorectal cancer patients.

Farouk, Sally; El-Shenawy, Reem; Khairy, Ahmed M; Bader El-Din, Noha G

Farouk, Sally; El-Shenawy, Reem; Khairy, Ahmed M; Bader El-Din, Noha G.

Afiliação

Farouk S; Department of Microbial Biotechnology, National Research Centre, Dokki, 12622, Egypt.
El-Shenawy R; Department of Microbial Biotechnology, National Research Centre, Dokki, 12622, Egypt.
Khairy AM; Department of Endemic Medicine, Faculty of Medicine, Cairo University, Giza, 11562, Egypt.
Bader El-Din NG; Department of Microbial Biotechnology, National Research Centre, Dokki, 12622, Egypt.

Biomark Med ; 17(3): 159-169, 2023 02.

Article em En | MEDLINE | ID: mdl-37097025

Molecules called miRNAs, found in blood, have a key role in colon cancer progression. This evidence highlights the importance of studying the role of some miRNAs in colorectal cancer (CRC) patients. miRNAs are one of the most recent targets for CRC screening and prognosis. miR-26a and -26b showed high overexpression in CRC patients. Results showed that both miR-26a and -26b had high diagnostic efficacy for CRC.

Assuntos

Neoplasias Colorretais; MicroRNAs; Humanos; MicroRNAs/genética; MicroRNAs/metabolismo; Metaloproteinase 9 da Matriz/genética; Metaloproteinase 9 da Matriz/metabolismo; Neoplasias Colorretais/diagnóstico; Neoplasias Colorretais/genética; Biomarcadores; Regulação Neoplásica da Expressão Gênica; Biomarcadores Tumorais/genética

Palavras-chave

MMP-9; colorectal cancer; diagnostic biomarkers; miRNAs; relative expression

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / MicroRNAs Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / MicroRNAs Idioma: En Ano de publicação: 2023 Tipo de documento: Article