Effects of age on the diagnostic value of the soluble fms-like tyrosine kinase-1/ placental growth factor ratio in preeclampsia: a retrospective cohort study.
J Hypertens
; 41(8): 1258-1264, 2023 08 01.
Article
em En
| MEDLINE
| ID: mdl-37115818
ABSTRACT
OBJECTIVE:
Measurement of the ratio between soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) supports the diagnosis of preeclampsia. sFlt-1/PlGF ratios of at least 85 and at least 110 have previously been suggested for diagnosis of early-onset and late-onset preeclampsia, respectively. However, angiogenic and antiangiogenic factors change throughout the process of aging, potentially influencing preeclampsia diagnosis. In this study, we therefore evaluated in detail the effect of maternal age on sFlt-1/PlGF ratios.METHODS:
A total of 2775 pregnant female patients were included in this retrospective cohort study, spread across three maternal age groups 18-25âyears, 26-35âyears, and more than 35âyears at delivery. Receiver-operating characteristic (ROC) curve analysis was employed to evaluate sFlt-1/PlGF ratio cutoffs for use in preeclampsia diagnosis.RESULTS:
Controls (2462 pregnant women) showed a significant difference in sFlt-1/PlGF ratios between the youngest and oldest age groups, which resulted in differences in the best-performing sFlt-1/PlGF ratio cutoffs optimized cutoffs were 143.4 (52.9%, 98.2%), 8.6 (84.4%, 75.3%), and 22.9 (78.6%, 82.3%) in early-onset preeclampsia, and 46.4 (67.5%, 81.5%), 40.8 (77.3%, 73%), and 44.1 (65.1%, 74.5%) in late-onset preeclampsia in age groups, 1, 2, and 3, respectively.CONCLUSION:
sFlt-1/PlGF ratios change with maternal age, which has important clinical implications for their use in the diagnosis of preeclampsia Better differentiated sFlt-1/PlGF cutoffs should be used that take maternal and gestational age into account.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article