Hypoxia Induces Tumor-Derived Exosome SNHG16 to Mediate Nasopharyngeal Carcinoma Progression through the miR-23b-5p/MCM6 Pathway.
Appl Biochem Biotechnol
; 196(1): 275-295, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37119503
ABSTRACT
This study aims to investigate the mechanism of tumor-derived exosomal (EVs) SNHG16 in promoting the progression of nasopharyngeal carcinoma (NPC). QRT-PCR was used to detect the expression of SNHG16, miR-23b-5p and MCM6 in NPC. MTT, flow cytometry and transwell were used to detect the effects of them on the proliferation, cycle, apoptosis and invasion ability of NPC. Transmission electron microscopy, Western blotting and BCA were used to verify the regulation of exosome secretion under different oxygen environments. Our results showed that hypoxia induces tumor-derived exosome SNHG16 to mediate NPC progression through the miR-23b-5p/MCM6 pathway.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Nasofaríngeas
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MicroRNAs
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Exossomos
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RNA Longo não Codificante
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article