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A Phase 1 First-in-Human Pharmacokinetic and Pharmacodynamic Study of JNJ-64264681, a Covalent Inhibitor of Bruton's Tyrosine Kinase.
Leu, Jocelyn H; Miao, Xin; Shalayda, Kevin; Coe, Kevin J; Kahnt, Ariane; Wu, Bonnie; Schnarr, Megan; Franks, Carol; Devlin, James; Yang, Tong-Yuan; Palmer, James A; Zhang, Mai; Zhou, Honghui; Van Damme, Wim; Smets, Sophie; Aguilar, Zuleima; Chaplan, Sandra R.
Afiliação
  • Leu JH; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.
  • Miao X; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.
  • Shalayda K; Janssen Research & Development, LLC, Raritan, New Jersey, USA.
  • Coe KJ; Janssen Research & Development, LLC, San Diego, California, USA.
  • Kahnt A; Janssen Research & Development, Beerse, Belgium.
  • Wu B; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.
  • Schnarr M; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.
  • Franks C; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.
  • Devlin J; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.
  • Yang TY; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.
  • Palmer JA; Janssen Research & Development, LLC, San Diego, California, USA.
  • Zhang M; Janssen Research & Development, LLC, San Diego, California, USA.
  • Zhou H; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.
  • Van Damme W; Present affiliation: Kira Pharmaceuticals, Cambridge, Massachusetts, USA.
  • Smets S; Clinical Pharmacology Unit, Janssen Research & Development, Merksem, Belgium.
  • Aguilar Z; Clinical Pharmacology Unit, Janssen Research & Development, Merksem, Belgium.
  • Chaplan SR; Janssen Research & Development, LLC, San Diego, California, USA.
Clin Pharmacol Drug Dev ; 12(6): 611-624, 2023 06.
Article em En | MEDLINE | ID: mdl-37125450
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tirosina Quinase da Agamaglobulinemia Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tirosina Quinase da Agamaglobulinemia Idioma: En Ano de publicação: 2023 Tipo de documento: Article