Therapeutic outcome of quercetin nanoparticles on Cerastes cerastes venom-induced hepatorenal toxicity: a preclinical study.
Nanomedicine (Lond)
; 18(4): 367-390, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-37125660
ABSTRACT
Aim:
The objective of this study was to investigate the therapeutic potential of quercetin (QT) and QT-loaded poly(lactic-co-glycolic acid) nanoparticles (QT-NPs) on Cerastes cerastes venom-mediated inflammation, redox imbalance, hepatorenal tissue damage and local hemorrhage.Methods:
The developed QT-NPs were first submitted to physicochemical characterization and then evaluated in the 'challenge then treat' and 'preincubation' models of envenoming.Results:
QT-NPs efficiently alleviated hepatorenal toxicity, inflammation and redox imbalance and significantly attenuated venom-induced local hemorrhage. Interestingly, QT-NPs were significantly more efficient than free QT at 24 h postenvenoming, pointing to the efficacy of this drug-delivery system.Conclusion:
These findings highlight the therapeutic potential of QT-NPs on venom-induced toxicity and open up the avenue for their use in the management of snakebite envenoming.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Viperidae
/
Nanopartículas
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article