ALS-causing hPFN1 mutants differentially disrupt LLPS of FUS prion-like domain.

Kang, Jian; Lim, Liangzhong; Song, Jianxing

Kang, Jian; Lim, Liangzhong; Song, Jianxing.

Afiliação

Kang J; Department of Biological Sciences, Faculty of Science, National University of Singapore, 10 Kent Ridge Crescent, 119260, Singapore.
Lim L; Department of Biological Sciences, Faculty of Science, National University of Singapore, 10 Kent Ridge Crescent, 119260, Singapore.
Song J; Department of Biological Sciences, Faculty of Science, National University of Singapore, 10 Kent Ridge Crescent, 119260, Singapore. Electronic address: dbssjx@nus.edu.sg.

Biochem Biophys Res Commun ; 664: 35-42, 2023 07 05.

Article em En | MEDLINE | ID: mdl-37130459

Assuntos

Esclerose Lateral Amiotrófica; Príons; Humanos; Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/metabolismo; Mutação; Espectroscopia de Ressonância Magnética; Imageamento por Ressonância Magnética; Príons/metabolismo; Proteína FUS de Ligação a RNA/genética; Proteína FUS de Ligação a RNA/metabolismo

Palavras-chave

ALS-Causing mutants of profilin-1; Amyotrophic lateral sclerosis (ALS); FUS prion-Like domain (PLD); Liquid-liquid phase separation (LLPS); NMR spectroscopy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Príons / Esclerose Lateral Amiotrófica Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Príons / Esclerose Lateral Amiotrófica Idioma: En Ano de publicação: 2023 Tipo de documento: Article