Mini-review: the distinct roles of STING signaling in tumor immunity-recent progress.
J Leukoc Biol
; 114(2): 111-115, 2023 07 27.
Article
em En
| MEDLINE
| ID: mdl-37141382
ABSTRACT
New strategies targeting STING proteins appear promising for eliciting immunotherapeutic responses. Activation of the STING pathway under the right circumstances can drive dendritic cell maturation, antitumor macrophage differentiation, T-cell initiation and activation, natural killer cell activation, vascular reprogramming, and/or cancer cell death, leading to immune-mediated tumor elimination and generation of antitumor immune memory. However, activation of the STING signaling pathway is complicated in tumor immunity. On one hand, STING signaling was found to promote tumor growth. On the other hand, the cGAS-STING pathway has great potential for regulating antitumor immunity. The development of activators of the cGAS-STING pathway may profoundly change tumor immunotherapy, providing an excellent direction for the development and clinical application of immunotherapeutic strategies for related diseases. This review provides a concise summary of the role of the STING pathway in tumors in recent years.
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Memória Imunológica
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article