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Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in Children.
Cleary, Yumi; Kletzl, Heidemarie; Grimsey, Paul; Heinig, Katja; Ogungbenro, Kayode; Silber Baumann, Hanna Elisabeth; Frey, Nicolas; Aarons, Leon; Galetin, Aleksandra; Gertz, Michael.
Afiliação
  • Cleary Y; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. yumi.cleary@roche.com.
  • Kletzl H; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK. yumi.cleary@roche.com.
  • Grimsey P; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Heinig K; Roche Pharma Research and Early Development, Roche Innovation Center, Welwyn, UK.
  • Ogungbenro K; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Silber Baumann HE; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
  • Frey N; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Aarons L; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Galetin A; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
  • Gertz M; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
Clin Pharmacokinet ; 62(6): 891-904, 2023 06.
Article em En | MEDLINE | ID: mdl-37148485

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP3A / Modelos Biológicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP3A / Modelos Biológicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article