'Persistent germinal center responses: slow-growing trees bear the best fruits'.
Curr Opin Immunol
; 83: 102332, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-37150126
ABSTRACT
Germinal centers (GCs) are key microanatomical sites in lymphoid organs where responding B cells mature and undergo affinity-based selection. The duration of the GC reaction has long been assumed to be relatively brief, but recent studies in humans, nonhuman primates, and mice indicate that GCs can last for weeks to months after initial antigen exposure. This review examines recent studies investigating the factors that influence GC duration, including antigen persistence, T-follicular helper cells, and mode of immunization. Potential mechanisms for how persistent GCs influence the B-cell repertoire are considered. Overall, these studies provide a blueprint for how to design better vaccines that elicit persistent GC responses.
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Base de dados:
MEDLINE
Assunto principal:
Árvores
/
Linfócitos T Auxiliares-Indutores
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article