Azole derivatives inhibit wildtype butyrylcholinesterase and its common mutants.

Sari, Suat; Önder, Seda; Akkaya, Didem; Sabuncuoglu, Suna; Zengin, Merve; Barut, Burak; Karakurt, Arzu

Sari, Suat; Önder, Seda; Akkaya, Didem; Sabuncuoglu, Suna; Zengin, Merve; Barut, Burak; Karakurt, Arzu.

Afiliação

Sari S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Önder S; Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Akkaya D; Department of Biochemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey.
Sabuncuoglu S; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Zengin M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Barut B; Department of Biochemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey.
Karakurt A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Inönü University, Malatya, Turkey.

Drug Dev Res ; 84(5): 1018-1028, 2023 08.

Article em En | MEDLINE | ID: mdl-37154110

Assuntos

Acetilcolinesterase; Butirilcolinesterase; Butirilcolinesterase/genética; Butirilcolinesterase/metabolismo; Acetilcolinesterase/genética; Acetilcolinesterase/metabolismo; Azóis/farmacologia; Inibidores da Colinesterase/farmacologia; Ésteres; Simulação de Acoplamento Molecular; Relação Estrutura-Atividade

Palavras-chave

acetylcholinesterase; butyrylcholinesterase; enzyme kinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Butirilcolinesterase Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Butirilcolinesterase Idioma: En Ano de publicação: 2023 Tipo de documento: Article