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Enlarged perivascular spaces and plasma Aß42/Aß40 ratio in older adults without dementia.
Kapoor, Arunima; Gaubert, Aimée; Yew, Belinda; Jang, Jung Yun; Dutt, Shubir; Li, Yanrong; Alitin, John Paul M; Nguyen, Amy; Ho, Jean K; Blanken, Anna E; Sible, Isabel J; Marshall, Anisa; Shenasa, Fatemah; Rodgers, Kathleen E; Martini, Alessandra C; Head, Elizabeth; Nation, Daniel A.
Afiliação
  • Kapoor A; Department of Psychological Science, University of California, Irvine, Irvine, CA, USA.
  • Gaubert A; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
  • Yew B; Department of Psychology, University of Southern California, Los Angeles, CA, USA.
  • Jang JY; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
  • Dutt S; Department of Psychology, University of Southern California, Los Angeles, CA, USA.
  • Li Y; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
  • Alitin JPM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
  • Nguyen A; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
  • Ho JK; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
  • Blanken AE; San Francisco Veterans Affairs Health Care System & Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
  • Sible IJ; Department of Psychology, University of Southern California, Los Angeles, CA, USA.
  • Marshall A; Department of Psychology, University of Southern California, Los Angeles, CA, USA.
  • Shenasa F; Department of Psychological Science, University of California, Irvine, Irvine, CA, USA.
  • Rodgers KE; Center for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
  • Martini AC; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
  • Head E; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
  • Nation DA; Department of Psychological Science, University of California, Irvine, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA. Electronic address: dnation@uci.edu.
Neurobiol Aging ; 128: 43-48, 2023 08.
Article em En | MEDLINE | ID: mdl-37156179
Dilation of perivascular spaces (PVS) in the brain may indicate poor fluid drainage due to the accumulation of perivascular cell debris, waste, and proteins, including amyloid-beta (Aß). No prior study has assessed whether plasma Aß levels are related to PVS in older adults without dementia. Independently living older adults (N = 56, mean age = 68.2 years; Standard deviation (SD) = 6.5; 30.4% male) free of dementia or clinical stroke were recruited from the community and underwent brain MRI and venipuncture. PVS were qualitatively scored and dichotomized to low PVS burden (scores 0-1,) or high PVS burden (score>1). Plasma was assayed using a Quanterix Simoa Kit to quantify Aß42 and Aß40 levels. A significant difference was observed in plasma Aß42/Aß40 ratio between low and high PVS burden, controlling for age (F[1, 53] = 5.59, p = 0.022, η2 = 0.10), with lower Aß42/Aß40 ratio in the high PVS burden group. Dilation of PVS is associated with a lower plasma Aß42/Aß40 ratio, which may indicate higher cortical amyloid deposition. Future longitudinal studies examining PVS changes, and the pathogenesis of AD are warranted.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article