The Expanded Central Dogma: Genome Resynthesis, Orthogonal Biosystems, Synthetic Genetics.
Annu Rev Biophys
; 52: 413-432, 2023 05 09.
Article
em En
| MEDLINE
| ID: mdl-37159296
ABSTRACT
Synthetic biology seeks to probe fundamental aspects of biological form and function by construction [i.e., (re)synthesis] rather than deconstruction (analysis). In this sense, biological sciences now follow the lead given by the chemical sciences. Synthesis can complement analytic studies but also allows novel approaches to answering fundamental biological questions and opens up vast opportunities for the exploitation of biological processes to provide solutions for global problems. In this review, we explore aspects of this synthesis paradigm as applied to the chemistry and function of nucleic acids in biological systems and beyond, specifically, in genome resynthesis, synthetic genetics (i.e., the expansion of the genetic alphabet, of the genetic code, and of the chemical make-up of genetic systems), and the elaboration of orthogonal biosystems and components.
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Nucleicos
/
Código Genético
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article