Association of antenatal corticosteroids with kidney function in adolescents born preterm with very low birth weight.
J Perinatol
; 43(8): 1038-1044, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-37160975
ABSTRACT
OBJECTIVE:
Investigate if antenatal corticosteroids (ANCS) are associated with worse kidney function in adolescence and if greater adiposity magnifies this association. STUDYDESIGN:
Prospective cohort of 162 14-year-olds born preterm with very low birth weight (<1500 g). Outcomes were estimated glomerular filtration rate (eGFR) and first-morning urine albumin-to-creatinine ratio (UACR). We used adjusted generalized linear models, stratified by waist-to-height ratio (WHR) ≥ 0.5.RESULTS:
Fifty-five percent had ANCS exposure and 31.3% had WHR ≥ 0.5. In adjusted analyses of the entire cohort, ANCS was not significantly associated with eGFR or UACR. However, the ANCS-eGFR association was greater in those with WHR ≥ 0.5 (ß -16.8 ml/min/1.73 m2, 95% CL -31.5 to -2.1) vs. WHR < 0.5 (ß 13.9 ml/min/1.73 m2, 95% CL -0.4 to 28.1), interaction term p = 0.02.CONCLUSION:
ANCS exposure was not associated with worse kidney function in adolescence, though ANCS may be associated with lower eGFR if children develop obesity by adolescence.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido de muito Baixo Peso
/
Obesidade
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article