Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes).

Lu, Cheng-Wei; Lin, Tzu-Yu; Hsieh, Pei-Wen; Chiu, Kuan-Ming; Lee, Ming-Yi; Wang, Su-Jane

Lu, Cheng-Wei; Lin, Tzu-Yu; Hsieh, Pei-Wen; Chiu, Kuan-Ming; Lee, Ming-Yi; Wang, Su-Jane.

Afiliação

Lu CW; Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City, 22060, Taiwan; Department of Mechanical Engineering, Yuan Ze University, Taoyuan, 32003, Taiwan.
Lin TY; Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City, 22060, Taiwan; Department of Mechanical Engineering, Yuan Ze University, Taoyuan, 32003, Taiwan.
Hsieh PW; Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan City, Taiwan; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, And Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung
Chiu KM; Division of Cardiovascular Surgery, Cardiovascular Center, Far-Eastern Memorial Hospital, New Taipei City, 22060, Taiwan; Department of Electrical Engineering, Yuan Ze University, Taoyuan, 32003, Taiwan.
Lee MY; Department of Medical Research, Far-Eastern Memorial Hospital, New Taipei, 22060, Taiwan.
Wang SJ; Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan City, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, 24205, Taiwan. Electronic address: med0003@mail.fju.edu.tw.

Neurochem Int ; 167: 105537, 2023 Jul.

Article em En | MEDLINE | ID: mdl-37164158

Assuntos

Cynara scolymus; Ácido Glutâmico; Ratos; Animais; Ácido Glutâmico/metabolismo; Ratos Sprague-Dawley; Cynara scolymus/metabolismo; Sinaptossomos/metabolismo; Sinapsinas/metabolismo; Sinapsinas/farmacologia; Simulação de Acoplamento Molecular; Potenciais da Membrana; 4-Aminopiridina/farmacologia; Canais de Cálcio Tipo P/metabolismo; Córtex Cerebral/metabolismo; Cálcio/metabolismo; Bloqueadores dos Canais de Cálcio/farmacologia; Terminações Pré-Sinápticas/metabolismo

Palavras-chave

Cynarin; Glutamate exocytotic inhibition; P/Q-type Ca(2+) channel; PKA; Synaptic proteins; Synaptosome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Glutâmico / Cynara scolymus Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Glutâmico / Cynara scolymus Idioma: En Ano de publicação: 2023 Tipo de documento: Article