Fatter Is Better: Boosting the Vascularization of Adipose Tissue Grafts.
Tissue Eng Part B Rev
; 29(6): 605-622, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37166386
ABSTRACT
Adipose tissue resorption after fat grafting is a major drawback in plastic and reconstructive surgery, which is primarily caused by the insufficient blood perfusion of the grafts in the initial phase after transplantation. To overcome this problem, several promising strategies to boost the vascularization and, thus, increase survival rates of fat grafts have been developed in preclinical studies in recent years. These include the angiogenic stimulation of the grafts by growth factors and botulinum neurotoxin A, biologically active gels, and cellular enrichment, as well as the physical and pharmacological stimulation of the transplantation site. To transfer these approaches into future clinical practice, it will be necessary to establish standardized procedures for their safe application in humans. If this succeeds, the surgical outcomes of fat grafting may be markedly improved, resulting in a significant reduction of the physical and psychological stress for the patients.
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Base de dados:
MEDLINE
Assunto principal:
Procedimentos de Cirurgia Plástica
/
Transplante de Células-Tronco Mesenquimais
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article