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The plasma levels of Dickkopf-1 elevated in patients with Juvenile Idiopathic Arthritis.
Ye, Lili; Jin, Yingying; Huang, Hua; Ding, Fei; Xu, Xuemei; Liu, Chenxi; Bao, Shengfang; Wu, Jing; Jin, Yanliang.
Afiliação
  • Ye L; Department of Rheumatology & Immunology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Jin Y; Department of Rheumatology & Immunology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Huang H; Department of Rheumatology & Immunology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Ding F; Department of Rheumatology & Immunology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Xu X; Department of Rheumatology & Immunology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Liu C; Department of Rheumatology & Immunology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Bao S; Department of Rheumatology & Immunology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Wu J; Institute of Pediatric Translational Medicine, Shanghai Children's Medical Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. wujingecnu@163.com.
  • Jin Y; Department of Rheumatology & Immunology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China. jinyanliang@scmc.com.cn.
Pediatr Res ; 94(4): 1349-1354, 2023 Oct.
Article em En | MEDLINE | ID: mdl-37179434
BACKGROUND: To explore the role of two major inhibitors of Wnt signal pathway, Dickkopf-1(DKK-1) and Sclerostin (SOST), in the pathogenesis of juvenile idiopathic arthritis (JIA). METHODS: 88 patients with JIA, which including 49 patients with enthesitis-related arthritis (ERA), 21 oligoarthritis (oJIA) and 18 polyarthritis (pJIA), and 36 age-and sex-matched children as healthy controls (HC) were enrolled in this study. The plasma levels of DKK-1 and SOST, measured using commercially available ELISA kits, were analyzed the correlation between the levels of DKK-1/SOST and JIA, and were analyzed in 14 patients with JIA during before and after treatment. RESULTS: Plasma levels of DKK-1 were significantly higher in the patients with JIA than that in HC, the elevation of DKK-1 level was positively correlated with HLA-B27 positive JIA. DKK-1 levels dropped significantly in patient with JIA after treatment (P < 0.05). There was no significant change in SOST levels among different subtypes of JIA, patients with JIA during before and after treatment, and HC. CONCLUSION: It was suggested that the DKK-1 may have a certain correlation with the pathogenesis of JIA, and DKK-1 levels are more closely related to the HLA-B27 positive-ERA. IMPACT: The abnormally elevated levels of Dickkopf-1 (DKK-1) may be involved in the pathogenesis of juvenile idiopathic arthritis (JIA). DKK-1 levels were more closely related to the HLA-B27 positive-enthesitis-related arthritis (ERA). DKK-1 is an inhibitor of Wnt signaling pathway that promotes osteoblastic new bone formation; it is very rare for pediatric patients with HLA-B27 positive-ERA to manifest typical spondylitis, while sacroiliac arthritis is relatively common, which may be related to the high levels of DKK-1, which is consistent with the early stage of ankylosing spondylitis (AS).
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Juvenil Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Juvenil Idioma: En Ano de publicação: 2023 Tipo de documento: Article