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Urinary neutrophil gelatinase-associated lipocalin and plasma IL-6 in discontinuation of continuous venovenous hemodiafiltration for severe acute kidney injury: a multicenter prospective observational study.
Komaru, Yohei; Oguchi, Moe; Sadahiro, Tomohito; Nakada, Taka-Aki; Hattori, Noriyuki; Moriguchi, Takeshi; Goto, Junko; Shiga, Hidetoshi; Kikuchi, Yoshihiko; Negi, Shigeo; Shigematsu, Takashi; Kuriyama, Naohide; Nakamura, Tomoyuki; Doi, Kent.
Afiliação
  • Komaru Y; Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, Tokyo, Japan.
  • Oguchi M; Department of Emergency and Critical Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.
  • Sadahiro T; Department of Emergency and Critical Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.
  • Nakada TA; Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Hattori N; Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Moriguchi T; Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan.
  • Goto J; Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan.
  • Shiga H; Emergency and Intensive Care Center, Teikyo University Chiba Medical Center, Chiba, Japan.
  • Kikuchi Y; Emergency and Intensive Care Center, Teikyo University Chiba Medical Center, Chiba, Japan.
  • Negi S; Department of Nephrology, Wakayama Medical University, Wakayama, Japan.
  • Shigematsu T; Department of Nephrology, Wakayama Medical University, Wakayama, Japan.
  • Kuriyama N; Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Aichi, Japan.
  • Nakamura T; Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Aichi, Japan.
  • Doi K; Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 1138655, Japan. kentdoi@m.u-tokyo.ac.jp.
Ann Intensive Care ; 13(1): 42, 2023 May 15.
Article em En | MEDLINE | ID: mdl-37184598
BACKGROUND: Patients with severe acute kidney injury (AKI) who require continuous venovenous hemodiafiltration (CVVHDF) in intensive care unit (ICU) are at high mortality risk. Little is known about clinical biomarkers for risk prediction, optimal initiation, and optimal discontinuation of CVVHDF. METHODS: This prospective observational study was conducted in seven university-affiliated ICUs. For urinary neutrophil gelatinase-associated lipocalin (NGAL) and plasma IL-6 measurements, samples were collected at initiation, 24 h, 48 h after, and CVVHDF discontinuation in adult patients with severe AKI. The outcomes were deaths during CVVHDF and CVVHDF dependence. RESULTS: A total number of 133 patients were included. Twenty-eight patients died without CVVHDF discontinuation (CVVHDF nonsurvivors). Urinary NGAL and plasma IL-6 at the CVVHDF initiation were significantly higher in CVVHDF nonsurvivors than in survivors. Among 105 CVVHDF survivors, 70 patients were free from renal replacement therapy (RRT) or death in the next 7 days after discontinuation (success group), whereas 35 patients died or needed RRT again (failure group). Urinary NGAL at CVVHDF discontinuation was significantly lower in the success group (93.8 ng/ml vs. 999 ng/ml, p < 0.01), whereas no significant difference was observed in plasma IL-6 between the groups. Temporal elevations of urinary NGAL levels during the first 48 h since CVVHDF initiation were observed in CVVHDF nonsurvivors and those who failed in CVVHDF discontinuation. CONCLUSIONS: Urinary NGAL at CVVHDF initiation and discontinuation was associated with mortality and RRT dependence, respectively. The serial changes of urinary NGAL might also help predict the prognosis of patients with AKI on CVVHDF.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article