Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor ß pathway in monocrotaline-induced pulmonary hypertension in rats.

Krzyzewska, Anna; Baranowska-Kuczko, Marta; Kasacka, Irena; Kozlowska, Hanna

Krzyzewska, Anna; Baranowska-Kuczko, Marta; Kasacka, Irena; Kozlowska, Hanna.

Afiliação

Krzyzewska A; Department of Experimental Physiology and Pathophysiology, Medical University of Bialystok, Bialystok, Poland. Electronic address: anna.krzyzewska@umb.edu.pl.
Baranowska-Kuczko M; Department of Experimental Physiology and Pathophysiology, Medical University of Bialystok, Bialystok, Poland; Department of Clinical Pharmacy, Medical University of Bialystok, Bialystok, Poland.
Kasacka I; Department of Histology and Cytophysiology, Medical University of Bialystok, Bialystok, Poland.
Kozlowska H; Department of Experimental Physiology and Pathophysiology, Medical University of Bialystok, Bialystok, Poland.

Biochim Biophys Acta Mol Basis Dis ; 1869(6): 166753, 2023 08.

Article em En | MEDLINE | ID: mdl-37187449

Assuntos

Canabidiol; Insuficiência Cardíaca; Hipertensão Pulmonar; Ratos; Animais; Hipertensão Pulmonar/induzido quimicamente; Hipertensão Pulmonar/tratamento farmacológico; Hipertensão Pulmonar/metabolismo; Fator de Crescimento Transformador beta; Fibronectinas; Monocrotalina; Fator de Crescimento Transformador beta1/metabolismo; Fibrose

Palavras-chave

Cannabidiol; Fibrosis; Pulmonary hypertension; Remodeling; Right ventricle; TGF-ß1/SMAD2 pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canabidiol / Insuficiência Cardíaca / Hipertensão Pulmonar Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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