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Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury.
Kayagaki, Nobuhiko; Stowe, Irma B; Alegre, Kamela; Deshpande, Ishan; Wu, Shuang; Lin, Zhonghua; Kornfeld, Opher S; Lee, Bettina L; Zhang, Juan; Liu, John; Suto, Eric; Lee, Wyne P; Schneider, Kellen; Lin, WeiYu; Seshasayee, Dhaya; Bhangale, Tushar; Chalouni, Cecile; Johnson, Matthew C; Joshi, Prajakta; Mossemann, Jan; Zhao, Sarah; Ali, Danish; Goldenberg, Neil M; Sayed, Blayne A; Steinberg, Benjamin E; Newton, Kim; Webster, Joshua D; Kelly, Ryan L; Dixit, Vishva M.
Afiliação
  • Kayagaki N; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA. kayagaki@gene.com.
  • Stowe IB; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
  • Alegre K; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
  • Deshpande I; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
  • Wu S; Department of Structural Biology, Genentech, South San Francisco, CA, USA.
  • Lin Z; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA.
  • Kornfeld OS; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA.
  • Lee BL; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
  • Zhang J; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
  • Liu J; Department of Translational Immunology, Genentech, South San Francisco, CA, USA.
  • Suto E; Department of Translational Immunology, Genentech, South San Francisco, CA, USA.
  • Lee WP; Department of Translational Immunology, Genentech, South San Francisco, CA, USA.
  • Schneider K; Department of Translational Immunology, Genentech, South San Francisco, CA, USA.
  • Lin W; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA.
  • Seshasayee D; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA.
  • Bhangale T; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA.
  • Chalouni C; Department of Human Genetics, Genentech, South San Francisco, CA, USA.
  • Johnson MC; Department of Pathology, Genentech, South San Francisco, CA, USA.
  • Joshi P; Department of Structural Biology, Genentech, South San Francisco, CA, USA.
  • Mossemann J; Department of Biomolecular Resources, Genentech, South San Francisco, CA, USA.
  • Zhao S; Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Ali D; Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Goldenberg NM; Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Sayed BA; Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Steinberg BE; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Newton K; Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Webster JD; Division of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Kelly RL; Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Dixit VM; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
Nature ; 618(7967): 1072-1077, 2023 Jun.
Article em En | MEDLINE | ID: mdl-37196676
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Membrana Celular / Inflamação / Fígado / Anticorpos Monoclonais / Fatores de Crescimento Neural Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Membrana Celular / Inflamação / Fígado / Anticorpos Monoclonais / Fatores de Crescimento Neural Idioma: En Ano de publicação: 2023 Tipo de documento: Article