Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study.
Korean J Intern Med
; 38(4): 526-533, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-37198877
ABSTRACT
BACKGROUND/AIMS:
A re-increasing trend of thyroid cancer since 2015 has been observed despite a similar examination rate, and the incidence of thyroid cancer among young adults continues to rise.METHODS:
This study used data from the Korean National Health Insurance Service. Individuals 20-39 years of age who underwent ≥ 4 health checkups from 2009-2013 were enrolled and followed throughout 2019. To quantify the metabolic burden, groups were divided by the number of diagnoses of metabolic syndrome across four consecutive health examinations.RESULTS:
Among the study population (n = 1,204,646), 5,929 (0.5%) were diagnosed with thyroid cancer during a follow- up period of 5 years. The hazard ratio (95% confidence interval) values of thyroid cancer occurrence according to the number (1-4) of diagnoses of metabolic syndrome across the four health examinations compared to the group without metabolic syndrome were significantly greater, as follows 1.12 (1.02-1.23), 1.25 (1.10-1.42), 1.33 (1.15-1.55), and 1.48 (1.25-1.75) (p for trend < 0.01), respectively. Each component of metabolic syndrome showed a significant increase in hazard ratio according to the number of diagnoses except for impaired fasting glucose criteria.CONCLUSION:
Cumulative exposure to metabolic syndrome was associated with thyroid cancer risk in young adults.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Glândula Tireoide
/
Síndrome Metabólica
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article