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Cardiac amyloidosis presenting as pulmonary arterial hypertension: A case report.
Gao, Ming; Zhang, Wei-Hua; Zhang, Zhi-Guo; Yang, Na; Tong, Qian; Chen, Li-Ping.
Afiliação
  • Gao M; Department of Cardiology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China. gmbeata@jlu.edu.cn.
  • Zhang WH; Department of Cardiology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
  • Zhang ZG; Department of Cardiology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
  • Yang N; Department of Cardiology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
  • Tong Q; Department of Cardiology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
  • Chen LP; Department of Echocardiography, Center of Cardiovascular Disease, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
World J Clin Cases ; 11(12): 2780-2787, 2023 Apr 26.
Article em En | MEDLINE | ID: mdl-37214585
ABSTRACT

BACKGROUND:

Pulmonary hypertension is a rare cardiopulmonary disease, with an insidious onset that usually worsens rapidly. Amyloid light chain (AL) amyloidosis is a rare systemic disease caused by extracellular deposition of pathologic, insoluble, and proteinaceous fibrils in organs and tissues; however, it is difficult to diagnose given its varied and nonspecific symptoms. To date, rare cases of amyloidosis with pulmonary hypertension have been reported. Of note, the optimal treatments for cardiac amyloidosis complicated with pulmonary hypertension remain unclear. CASE

SUMMARY:

We report a case of a 51-year-old woman who presented with progressively worsening dyspnea. Transthoracic echocardiography indicated severe pulmonary hypertension. Twenty-seven months after first admission, the patient returned with symptoms of progressive heart failure. A myocardial tissue sample stained with Congo red was positive, and the patient was ultimately diagnosed with AL amyloidosis with cardiac involvement.

CONCLUSION:

Although pulmonary hypertension may be idiopathic, it is frequently associated with other conditions. In rare cases, pulmonary hypertension can be a complication of AL amyloidosis, which should be seriously considered in any adult presenting with nonspecific signs or symptoms of cardiac distress.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article