Zn(II)-catalysed enantioselective addition of alcohols and tert-butyl hydroperoxide to isatin-derived N-Boc ketimines.
Chem Commun (Camb)
; 59(46): 7096-7099, 2023 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-37218456
ABSTRACT
Using binaphthyl-proline-based chiral ligands, Zn(II)-catalysed addition of alcohols and tert-butyl hydroperoxide to isatin-derived N-Boc ketimines provided the isatin-derived C3 N,O-aminals in up to 99% yield and up to 99% ee. The reactions could be carried out under mild conditions and a gram-scale reaction could be realized without the loss of the yield and enantioselectivity.
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MEDLINE
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En
Ano de publicação:
2023
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Article