The Bcl-2/Bcl-xL Inhibitor ABT-263 Attenuates Retinal Degeneration by Selectively Inducing Apoptosis in Senescent Retinal Pigment Epithelial Cells.

Ryu, Wonseon; Park, Chul-Woo; Kim, Junghoon; Lee, Hyungwoo; Chung, Hyewon

Ryu, Wonseon; Park, Chul-Woo; Kim, Junghoon; Lee, Hyungwoo; Chung, Hyewon.

Afiliação

Ryu W; Department of Ophthalmology, Konkuk University School of Medicine, Seoul 05029, Korea.
Park CW; These authors contributed equally to this work.
Kim J; Department of Ophthalmology, Konkuk University School of Medicine, Seoul 05029, Korea.
Lee H; These authors contributed equally to this work.
Chung H; Department of Ophthalmology, Konkuk University School of Medicine, Seoul 05029, Korea.

Mol Cells ; 46(7): 420-429, 2023 Jul 31.

Article em En | MEDLINE | ID: mdl-37222160

Assuntos

Antineoplásicos; Degeneração Macular; Degeneração Retiniana; Animais; Camundongos; Senoterapia; Antineoplásicos/farmacologia; Degeneração Macular/metabolismo; Apoptose; Células Epiteliais/metabolismo; Pigmentos da Retina/farmacologia; Senescência Celular

Palavras-chave

ABT-263; Bcl-2/Bcl-xL; doxorubicin; senescence; senolytic

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração Retiniana / Degeneração Macular / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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