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Designing a Light-Induced Glycosylation Reaction for Poststage Synthesis of ADP-2″-Deoxyribosyl Derivatives.
Shen, Jiaojiao; Zhu, Gongming; You, Yanbo; Huo, Bianbian; Dai, Fangyin; Wang, Honglei; Zhu, Anlian; Li, Lingjun.
Afiliação
  • Shen J; Pingyuan Laboratory, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering,
  • Zhu G; Pingyuan Laboratory, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering,
  • You Y; State Key Laboratory of Cell Differentiation Regulation and Target Drug, Henan Normal University, Xinxiang, Henan 453007, P. R. China.
  • Huo B; Pingyuan Laboratory, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering,
  • Dai F; Pingyuan Laboratory, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering,
  • Wang H; State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, P. R. China.
  • Zhu A; Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, P. R. China.
  • Li L; Pingyuan Laboratory, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering,
Org Lett ; 25(21): 3961-3966, 2023 06 02.
Article em En | MEDLINE | ID: mdl-37222442
ABSTRACT
Modifications on the hydroxyl groups of ADP-ribosyl units can provide valuable tools for investigating ADP-ribosylation-related molecular interactions, but the chemical syntheses of these compounds are usually difficult due to their inherent complex structures. In this study, we report a poststage synthetic protocol for accessing novel ADP-2″-deoxyribosyl derivatives through designing a light-induced biomimetic reaction, and SPR assays revealed effective binding of ADP-2″-deoxyribosyl peptides to MacroH2A1.1 with a high affinity (KD = 3.75 × 10-6 M).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenosina Difosfato Ribose / ADP-Ribosilação Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenosina Difosfato Ribose / ADP-Ribosilação Idioma: En Ano de publicação: 2023 Tipo de documento: Article