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Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation.
Lin, Chun-Yu; Chen, Yi-Ju; Hsu, Chih-Hsuan; Lin, Yu-Hsuan; Chen, Peng-Tzu; Kuo, Ting-Han; Ho, Chris T; Chen, Hsin-Hua; Huang, Sih-Jia; Chiu, Ho-Chieh; Chen, Chin-Chu; Hwang, Eric.
Afiliação
  • Lin CY; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Taiwan.
  • Chen YJ; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan.
  • Hsu CH; Institute of Data Science and Engineering, National Yang Ming Chiao Tung University, Taiwan.
  • Lin YH; Center for Intelligent Drug Systems and Smart Bio-devices, National Yang Ming Chiao Tung University, Taiwan.
  • Chen PT; School of Dentistry, Kaohsiung Medical University, Taiwan.
  • Kuo TH; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan.
  • Ho CT; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan.
  • Chen HH; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan.
  • Huang SJ; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan.
  • Chiu HC; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan.
  • Chen CC; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan.
  • Hwang E; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Taiwan.
J Food Drug Anal ; 31(1): 32-54, 2023 03 15.
Article em En | MEDLINE | ID: mdl-37224554
ABSTRACT
Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Axônios / Neuroesteroides Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Axônios / Neuroesteroides Idioma: En Ano de publicação: 2023 Tipo de documento: Article