Potential angiogenic biomarkers in hereditary hemorrhagic telangiectasia and other vascular diseases.
Eur J Intern Med
; 115: 10-17, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37225595
ABSTRACT
Biomarkers are new tools framed in precision and personalized medicine. Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic vascular disease with disturbances in the angiogenic pathways. Descriptive evidence supports that some angiogenesis-related molecules are differently detected in HHT patients compared to healthy subjects. These molecules are also related to diagnosis, prognosis, complications and therapy monitoring in other common vascular diseases. Despite the need for improving knowledge before applying them in daily clinical practice, there are good candidates to be considered as potential biomarkers in HHT and other vascular diseases. In the present review, the authors aim to summarize and discuss current evidence regarding the main putative angiogenic biomarkers by describing the biological role of each biomarker, the evidence related to HHT and their potential use in this and other common vascular diseases from a clinical point-of-view.
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Base de dados:
MEDLINE
Assunto principal:
Telangiectasia Hemorrágica Hereditária
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article