Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease.
Nephron
; 148(1): 1-10, 2024.
Article
em En
| MEDLINE
| ID: mdl-37232009
ABSTRACT
BACKGROUND:
Due to the complexity of chronic kidney disease (CKD) pathophysiology, biomarkers representing different mechanistic pathways have been targeted for the study and development of novel biomarkers. The discovery of clinically useful CKD biomarkers would allow for the identification of those children at the highest risk of kidney function decline for timely interventions and enrollment in clinical trials.SUMMARY:
Glomerular filtration rate and proteinuria are traditional biomarkers to classify and prognosticate CKD progression in clinical practice but have several limitations. Over the recent decades, novel biomarkers have been identified from blood or urine with metabolomic screening studies, proteomic screening studies, and an improved knowledge of CKD pathophysiology. This review highlights promising biomarkers associated with the progression of CKD that could potentially serve as future prognostic markers in children with CKD. KEY MESSAGES Further studies are needed in children with CKD to validate putative biomarkers, particularly candidate proteins and metabolites, for improving clinical management.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteômica
/
Insuficiência Renal Crônica
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article