Common Prognostic Biomarkers and Outcomes in Patients with COVID-19 Infection in Saudi Arabia.

Abujabal, Mashael; Shalaby, Mohamed A; Abdullah, Layla; Albanna, Amr S; Elzoghby, Mohamed; Alahmadi, Ghadeer Ghazi; Sethi, Sidharth Kumar; Temsah, Mohamad-Hani; Aljamaan, Fadi; Alhasan, Khalid; Kari, Jameela A

Abujabal, Mashael; Shalaby, Mohamed A; Abdullah, Layla; Albanna, Amr S; Elzoghby, Mohamed; Alahmadi, Ghadeer Ghazi; Sethi, Sidharth Kumar; Temsah, Mohamad-Hani; Aljamaan, Fadi; Alhasan, Khalid; Kari, Jameela A.

Afiliação

Abujabal M; Pediatric Nephrology Unit, Faculty of Medicine and Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Shalaby MA; Pediatric Nephrology Unit, Faculty of Medicine and Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Abdullah L; Pediatric Nephrology Unit, Faculty of Medicine and Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Albanna AS; King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Jeddah 14611, Saudi Arabia.
Elzoghby M; Pediatric Intensive Care Unit, Pediatrics Department, College of Medicine, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia.
Alahmadi GG; Department of Pediatric, College of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Sethi SK; Kidney and Renal Transplant Institute, Medanta, The Medicity Hospital, Gurgaon 122001, India.
Temsah MH; Pediatric Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Aljamaan F; Prince Abdullah bin Khaled Coeliac Disease Research Chair, King Saud University, Riyadh 11362, Saudi Arabia.
Alhasan K; Critical Care Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Kari JA; Pediatric Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.

Trop Med Infect Dis ; 8(5)2023 Apr 30.

Article em En | MEDLINE | ID: mdl-37235308

ABSTRACT

ABSTRACT

Background:

COVID-19 is a respiratory disease that eventually became a pandemic, with 300 million people infected around the world. Alongside the improvement in COVID-19 management and vaccine development, identifying biomarkers for COVID-19 has recently been reported to help in early prediction and managing severe cases, which might improve outcomes. Our study aimed to find out if there is any correlation between clinical severity and elevated hematological and biochemical markers in COVID-19 patients and its effect on the outcome.

Methods:

We have collected retrospective data on socio-demographics, medical history, biomarkers, and disease outcomes from five hospitals and health institutions in the Kingdom of Saudi Arabia.

Results:

Pneumonia was the most common presentation of COVID-19 in our cohort. The presence of abnormal inflammatory biomarkers (D-dimer, CRP, troponin, LDH, ferritin, and t white blood cells) was significantly associated with unstable COVID-19 disease. In addition, patients with evidence of severe respiratory disease, particularly those who required mechanical ventilation, had higher biomarkers when compared to those with stable respiratory conditions (p < 0.001).