Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis.

Hara, Yutaro; Mizukami, Hiroki; Yamazaki, Keisuke; Yamada, Takahiro; Igawa, Akiko; Takeuchi, Yuki; Sasaki, Takanori; Kushibiki, Hanae; Murakami, Kotaro; Kudoh, Kazuhiro; Ishido, Keinosuke; Hakamada, Kenichi

Hara, Yutaro; Mizukami, Hiroki; Yamazaki, Keisuke; Yamada, Takahiro; Igawa, Akiko; Takeuchi, Yuki; Sasaki, Takanori; Kushibiki, Hanae; Murakami, Kotaro; Kudoh, Kazuhiro; Ishido, Keinosuke; Hakamada, Kenichi.

Afiliação

Hara Y; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Mizukami H; Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Yamazaki K; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Yamada T; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Igawa A; Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Takeuchi Y; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Sasaki T; Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Kushibiki H; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Murakami K; Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Kudoh K; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Ishido K; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Hakamada K; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

J Pathol Clin Res ; 9(5): 354-366, 2023 09.

Article em En | MEDLINE | ID: mdl-37246239

Assuntos

Carcinoma Ductal Pancreático; Diabetes Mellitus; MicroRNAs; Neoplasias Pancreáticas; Humanos; beta Catenina/genética; Regulação para Baixo; Hemoglobinas Glicadas; Metilação de DNA; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/patologia; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/patologia; Caderinas/genética; Epigênese Genética; Prognóstico; Diabetes Mellitus/genética; MicroRNAs/genética; Neoplasias Pancreáticas

Palavras-chave

E-cadherin; diabetes mellitus; microRNA; pancreatic ductal adenocarcinoma; promoter methylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / MicroRNAs / Diabetes Mellitus Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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