A non-clinical and clinical IUCLID database for 530 pharmaceuticals (part I): Methodological aspects of its development.

Evangelisti, Martina; Parenti, Marco Daniele; Varchi, Greta; Franco, Jorge; Vom Brocke, Jochen; Karamertzanis, Panagiotis G; Del Rio, Alberto; Bichlmaier, Ingo

Evangelisti, Martina; Parenti, Marco Daniele; Varchi, Greta; Franco, Jorge; Vom Brocke, Jochen; Karamertzanis, Panagiotis G; Del Rio, Alberto; Bichlmaier, Ingo.

Afiliação

Evangelisti M; Innovamol Consulting Srl, Via San Faustino 167, 41126, Modena, Italy.
Parenti MD; Innovamol Consulting Srl, Via San Faustino 167, 41126, Modena, Italy; Institute for Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), Via P. Gobetti 101, I-40129 Bologna, Italy.
Varchi G; Institute for Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), Via P. Gobetti 101, I-40129 Bologna, Italy.
Franco J; Innovamol Consulting Srl, Via San Faustino 167, 41126, Modena, Italy; Genoa University, Via Balbi 5, 16126, Genoa, Italy.
Vom Brocke J; European Chemicals Agency (ECHA), Telakkakatu 6, 00150, Helsinki, Finland.
Karamertzanis PG; European Chemicals Agency (ECHA), Telakkakatu 6, 00150, Helsinki, Finland.
Del Rio A; Innovamol Consulting Srl, Via San Faustino 167, 41126, Modena, Italy; Institute for Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), Via P. Gobetti 101, I-40129 Bologna, Italy. Electronic address: alberto.delrio@innovamol.com.
Bichlmaier I; European Chemicals Agency (ECHA), Telakkakatu 6, 00150, Helsinki, Finland. Electronic address: ingo.bichlmaier@echa.europa.eu.

Regul Toxicol Pharmacol ; 142: 105416, 2023 Aug.

Article em En | MEDLINE | ID: mdl-37253405

Assuntos

Indústria Farmacêutica; Sistema Endócrino; Animais; Humanos; Bases de Dados Factuais; Preparações Farmacêuticas; Mamíferos

Palavras-chave

Animal testing; Animal-human correlation; Carcinogenicity; Developmental toxicity; Effect levels; Endocrine disruption; Human information; IUCLID database; NAMs; New approach methodologies; Ontology; Repeat-dose toxicity; Reproductive toxicity; Standard product label

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Indústria Farmacêutica / Sistema Endócrino Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Indústria Farmacêutica / Sistema Endócrino Idioma: En Ano de publicação: 2023 Tipo de documento: Article