Lignan glycosides from Fritillaria verticillata Willd. and their anti-inflammatory activities.
Fitoterapia
; 168: 105553, 2023 Jul.
Article
em En
| MEDLINE
| ID: mdl-37257697
ABSTRACT
Three undescribed lignan glycosides, echiunines E-G (1-3), as well as eight known compounds (4-11) were isolated from Fritillaria verticillata Willd. Among them, compounds 1-3 were a series of lignan glycosides reported for the first time from genus Fritillaria. Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously, the absolute configuration of compounds were further confirmed by calculated ECD method. The NO release inhibitory effects of compounds were evaluated in LPS-activated RAW264.7 macrophages. Compounds 7-8 showed inhibitory acitivities in a dose-dependent manner.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lignanas
/
Fritillaria
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article