Low-density Lipoprotein Receptor Activities, Lipids, Apolipoprotein, and Clinical Course of Patients with Steroid-resistant Nephrotic Syndrome Treated with Low-density Lipoprotein Apheresis: A Case Series.
Intern Med
; 63(3): 433-438, 2024 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-37258157
ABSTRACT
We herein report three cases of steroid-resistant nephrotic syndrome successfully treated with low-density lipoprotein apheresis (LDL-A). All patients were treated with a combination of steroids, cyclosporine, and LDL-A. In all cases, the serum concentrations of LDL, total and high-density lipoprotein cholesterol, and triglycerides were significantly lowered following LDL-A administration. Furthermore, the estimated LDL receptor activity increased, while both serum LDL and total cholesterol levels decreased, suggesting that LDL-A increases LDL receptor activity by driving changes in serum cholesterol concentration. This case series suggests that LDL-A increases LDL receptor activity, which may improve the intracellular uptake of cyclosporine.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Remoção de Componentes Sanguíneos
/
Glomerulosclerose Segmentar e Focal
/
Síndrome Nefrótica
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article