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The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling.
Boo, Hye-Jin; Min, Hye-Young; Hwang, Su Jung; Lee, Hyo-Jong; Lee, Jae-Won; Oh, Sei-Ryang; Park, Choon-Sik; Park, Jong-Sook; Lee, You Mie; Lee, Ho-Young.
Afiliação
  • Boo HJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
  • Min HY; Department of Histology, College of Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
  • Hwang SJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
  • Lee HJ; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
  • Lee JW; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
  • Oh SR; Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju-si, Chungcheongbuk-do, 28116, Republic of Korea.
  • Park CS; Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju-si, Chungcheongbuk-do, 28116, Republic of Korea.
  • Park JS; Soonchunhyang University Bucheon Hospital, Bucheon, Gyeonggi-do, 14584, Republic of Korea.
  • Lee YM; Soonchunhyang University Bucheon Hospital, Bucheon, Gyeonggi-do, 14584, Republic of Korea.
  • Lee HY; Vessel-Organ Interaction Research Center (VOICE, MRC), College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea.
Exp Mol Med ; 55(6): 1131-1144, 2023 06.
Article em En | MEDLINE | ID: mdl-37258578

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Nicotínicos / Neoplasias Pulmonares / Nitrosaminas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Nicotínicos / Neoplasias Pulmonares / Nitrosaminas Idioma: En Ano de publicação: 2023 Tipo de documento: Article