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Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity.
Zhang, Xian; Fan, Yinzhong; Ye, Ke; Pan, Xiaoyan; Ma, Xujun; Ai, Honglian; Shi, Baobao; Liu, Jikai.
Afiliação
  • Zhang X; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
  • Fan Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • Ye K; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
  • Pan X; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
  • Ma X; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
  • Ai H; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
  • Shi B; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
  • Liu J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Pharmaceuticals (Basel) ; 16(2)2023 Jan 28.
Article em En | MEDLINE | ID: mdl-37259342
ABSTRACT
Six previously undescribed cytochalasins, Curtachalasins X1-X6 (1-6), together with six known compounds (7-12) were isolated from the endophytic fungus Xylaria curta E10 harbored in the plant Solanum tuberosum. The structures were elucidated by the interpretation of HRESIMS, UV, and NMR data. The absolute configurations of Curtachalasins X1-X6 were determined by comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. In bioassays, Curtachalasin X1 (1) and X5 (5) showed cytotoxic activity against the MCF-7 cell line with IC50 values of 2.03 µM and 0.85 µM, respectively.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article