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Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.
Khrom, Michelle; Li, Dalin; Naito, Takeo; Lee, Ho-Su; Botwin, Gregory J; Potdar, Alka A; Boucher, Gabrielle; Yang, Shaohong; Mengesha, Emebet; Dube, Shishir; Song, Kyuyoung; McGovern, Dermot P B; Haritunians, Talin.
Afiliação
  • Khrom M; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Li D; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Naito T; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Lee HS; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Botwin GJ; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Potdar AA; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Boucher G; Research Center, Montreal Heart Institute, Montreal, Quebec, Canada.
  • Yang S; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Mengesha E; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Dube S; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Song K; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • McGovern DPB; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Haritunians T; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Inflamm Bowel Dis ; 29(10): 1622-1632, 2023 10 03.
Article em En | MEDLINE | ID: mdl-37262302
Sex-dimorphic meta-analyses of sex-stratified case-control (n = 73 704) regression identified 3 novel inflammatory bowel disease loci reaching genome-wide significance and highlighted chromosome 2 and major histocompatibility complex variants exhibiting sex-specific association. In addition, a novel chromosome X Crohn's disease susceptibility locus was identified.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa / Doença de Crohn Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa / Doença de Crohn Idioma: En Ano de publicação: 2023 Tipo de documento: Article