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Synchrotron-based FTIR evaluation of biochemical changes in cancer and noncancer cells induced by brominated marine coelenteramine.
Magalhaes, Carla M; Ducic, Tanja; Pereira, Renato B; González-Berdullas, Patricia; Rodríguez-Borges, José E; Pereira, David M; Esteves da Silva, Joaquim C G; Algarra, Manuel; Pinto da Silva, Luís.
Afiliação
  • Magalhaes CM; Chemistry Research Unit (CIQUP), Institute of Molecular Sciences (IMS), Department of Geosciences, Environment and Territorial Planning, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.
  • Ducic T; ALBA CELLS Synchrotron, Carrer de la Llum 2-26 08290 Cerdanyola del Vallès, Barcelona, Spain. Electronic address: tducic@cells.es.
  • Pereira RB; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, Nº 228, 4050-213, Porto, Portugal.
  • González-Berdullas P; Chemistry Research Unit (CIQUP), Institute of Molecular Sciences (IMS), Department of Geosciences, Environment and Territorial Planning, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.
  • Rodríguez-Borges JE; LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.
  • Pereira DM; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, Nº 228, 4050-213, Porto, Portugal.
  • Esteves da Silva JCG; Chemistry Research Unit (CIQUP), Institute of Molecular Sciences (IMS), Department of Geosciences, Environment and Territorial Planning, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.
  • Algarra M; INAMAT2 - Institute for Advanced Materials and Mathematics, Department of Science, Public University of Navarra, Campus de Arrosadia, 31006, Pamplona, Spain. Electronic address: manuel.algarra@unavarra.es.
  • Pinto da Silva L; Chemistry Research Unit (CIQUP), Institute of Molecular Sciences (IMS), Department of Geosciences, Environment and Territorial Planning, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal. Electronic address: luis.silva@fc.up.pt.
Arch Biochem Biophys ; 743: 109660, 2023 07 15.
Article em En | MEDLINE | ID: mdl-37263463
ABSTRACT
The mode of action toward gastric cancer cells of brominated Coelenteramine, an analogue of a metabolic product of a marine bioluminescent reaction, was investigated by synchrotron radiation-based Fourier Transform Infrared spectrocopy (FTIR). This method revealed that the anticancer activity of brominated Coelenteramine is closely connected with cellular lipids, by affecting their organization and composition. More specifically, there is an increasing extent of oxidative stress, which results in changes in membrane polarity, lipid chain packing and lipid composition. However, this effect was not observed in a noncancer cell line, helping to explain its selectivity profile. Thus, synchrotron radiation-based FTIR helped to identify the potential of this Coelenteramine analogue in targeting membrane lipids, while proving to be a powerful technique to probe the mechanism of anticancer drugs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síncrotrons / Neoplasias Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síncrotrons / Neoplasias Idioma: En Ano de publicação: 2023 Tipo de documento: Article