Hippo signaling in acute kidney injury to chronic kidney disease transition: Current understandings and future targets.
Drug Discov Today
; 28(8): 103649, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-37268185
ABSTRACT
Acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition is a slow but persistent progression toward end-stage kidney disease. Earlier reports have shown that Hippo components, such as Yes-associated protein (YAP) and its homolog Transcriptional coactivator with PDZ-binding motif (TAZ), regulate inflammation and fibrogenesis during the AKI-to-CKD transition. Notably, the roles and mechanisms of Hippo components vary during AKI, AKI-to-CKD transition, and CKD. Hence, it is important to understand these roles in detail. This review addresses the potential of Hippo regulators or components as future therapeutic targets for halting the AKI-to-CKD transition.
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Base de dados:
MEDLINE
Assunto principal:
Insuficiência Renal Crônica
/
Injúria Renal Aguda
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article