Nitrogen Atom Transfer Enables the (5+1) Annulation Reaction to Access Aminoisoquinolines.
Org Lett
; 25(23): 4270-4275, 2023 Jun 16.
Article
em En
| MEDLINE
| ID: mdl-37272676
ABSTRACT
Herein, a catalytic synthetic transformation offering a series of -NH2 group-bearing aminoisoquinolines with moderate to good yields has been showcased. Interestingly, the nitrogen atom of the isoquinoline ring is coming from the reaction medium upon metal-assisted C≡N bond cleavage. Moreover, this (5+1) annulation reaction shows broad substrate variation. Furthermore, the derivatization of the isoquinoline core via functional group interconversions and mechanistic studies to identify the reaction intermediate have been carried out successfully.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Isoquinolinas
/
Nitrogênio
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article