Neuropathic-like Nociception and Spinal Cord Neuroinflammation Are Dependent on the TRPA1 Channel in Multiple Sclerosis Models in Mice.

Dalenogare, Diéssica Padilha; Souza Monteiro de Araújo, Daniel; Landini, Lorenzo; Titiz, Mustafa; De Siena, Gaetano; De Logu, Francesco; Geppetti, Pierangelo; Nassini, Romina; Trevisan, Gabriela

Dalenogare, Diéssica Padilha; Souza Monteiro de Araújo, Daniel; Landini, Lorenzo; Titiz, Mustafa; De Siena, Gaetano; De Logu, Francesco; Geppetti, Pierangelo; Nassini, Romina; Trevisan, Gabriela.

Afiliação

Dalenogare DP; Graduated Program in Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil.
Souza Monteiro de Araújo D; Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Landini L; Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Titiz M; Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
De Siena G; Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
De Logu F; Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Geppetti P; Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Nassini R; Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Trevisan G; Graduated Program in Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil.

Cells ; 12(11)2023 05 30.

Article em En | MEDLINE | ID: mdl-37296632

Assuntos

Encefalomielite Autoimune Experimental; Esclerose Múltipla; Neuralgia; Canais de Potencial de Receptor Transitório; Feminino; Animais; Camundongos; Esclerose Múltipla/metabolismo; Encefalomielite Autoimune Experimental/metabolismo; Canal de Cátion TRPA1/metabolismo; Hiperalgesia/tratamento farmacológico; Nociceptividade; Canais de Potencial de Receptor Transitório/metabolismo; Doenças Neuroinflamatórias; Medula Espinal/metabolismo; Neuralgia/tratamento farmacológico

Palavras-chave

allodynia; astrocyte; microglia; neuroinflammation; oligodendrocyte; pain

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalomielite Autoimune Experimental / Canais de Potencial de Receptor Transitório / Esclerose Múltipla / Neuralgia Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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