Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive Review.
Int J Mol Sci
; 24(11)2023 May 28.
Article
em En
| MEDLINE
| ID: mdl-37298344
ABSTRACT
Solute carriers (SLCs) are essential for brain physiology and homeostasis due to their role in transporting necessary substances across cell membranes. There is an increasing need to further unravel their pathophysiological implications since they have been proposed to play a pivotal role in brain tumor development, progression, and the formation of the tumor microenvironment (TME) through the upregulation and downregulation of various amino acid transporters. Due to their implication in malignancy and tumor progression, SLCs are currently positioned at the center of novel pharmacological targeting strategies and drug development. In this review, we discuss the key structural and functional characteristics of the main SLC family members involved in glioma pathogenesis, along with their potential targeting options to provide new opportunities for CNS drug design and more effective glioma management.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Carreadoras de Solutos
/
Glioma
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article