Repurposing a plant alkaloid homoharringtonine targets insulinoma associated-1 in N-Myc-activated neuroblastoma.

Chen, Chiachen; Wu, Jiande; Hicks, Chindo; Lan, Michael S

Chen, Chiachen; Wu, Jiande; Hicks, Chindo; Lan, Michael S.

Afiliação

Chen C; Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar St. CSRB, New Orleans, LA 70112, USA.
Wu J; Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar St. CSRB, New Orleans, LA 70112, USA; Bioinformatics and Genomics Program, 533 Bolivar St. CSRB, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Hicks C; Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar St. CSRB, New Orleans, LA 70112, USA; Bioinformatics and Genomics Program, 533 Bolivar St. CSRB, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Lan MS; Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar St. CSRB, New Orleans, LA 70112, USA. Electronic address: mlan@lsuhsc.edu.

Cell Signal ; 109: 110753, 2023 09.

Article em En | MEDLINE | ID: mdl-37301315

Assuntos

Insulinoma; Neuroblastoma; Neoplasias Pancreáticas; Humanos; Criança; Mepesuccinato de Omacetaxina; Fosfatidilinositol 3-Quinases/metabolismo; Reposicionamento de Medicamentos; Linhagem Celular Tumoral; Neuroblastoma/genética; Neoplasias Pancreáticas/genética; Regulação Neoplásica da Expressão Gênica; Proteínas Repressoras/metabolismo

Palavras-chave

Alkaloid; Homoharringtonine; INSM1; MYCN proto-oncogene; Neuroblastoma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Insulinoma / Neuroblastoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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